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Answer:

9.0 Endo/Metabolic


     A:
  1. Increase insulin secretion by inhibiting ATP-dependent K+ channel --> cell membrane depol --> Ca++ influx --> release of stored insulin from secretory granules
  2. Decrease hepatic insulin clearance --> increased serum insulin concentrations

Harrigan RA, Nathan MS, Beattie P. Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment. Ann Emerg Med. July 2001;38:68-78. (LLSA 2004)



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